Based in the former House of Fraser store, Flannels boasts more than 200 designer brands for men, women and children - from established international designers to contemporary labels.
Monday’s opening marks the biggest luxury retail investment to date in the city, according to the company, with around £10 million spent transforming the 55,000 sq ft space ahead of its grand opening.
Michael Murray, FLANNELS’ Group head of elevation, said: “We’re confident we are introducing a truly world-class offering to Sheffield, and a beauty concept that disrupts the traditional.
"Continually ripping up the rule book and looking at retail spaces in a different way, this store will be the go-to luxury destination in the North.”
The brand already has an outlet at Shirebrook in Derbyshire.
The company has agreed a 15-year lease at Meadowhall. Scroll down for a first look inside.
![First look inside.](https://www.thestar.co.uk/webimg/b25lY21zOjFhYTk4NzY1LTg3MzgtNDkwNC1hZDkxLTc3MDNmMTU0MGU5ZjphNTJmN2M1ZC0yYTUyLTRlZmQtOGEyNS1iZjAzMjZmMzNiZWY=.jpg?crop=3:2&width=800)
![First look inside.](https://www.thestar.co.uk/webimg/b25lY21zOjM1ZTJkZDA3LWEwZTgtNGVmNS05NWYyLWM3MjcyMWM0NDkxODo2MTIxZTg1OS03MmRhLTRkM2QtYmM4Ni0yNmY2YzU2NjI3MmI=.jpg?crop=3:2&width=800)
![First look inside.](https://www.thestar.co.uk/webimg/b25lY21zOjFhYzVkYjRkLTAwMGEtNDczMi1iNGI1LWMxZThhZjg0ZDk4ODo1ZDgzZmI2Ni1mNjJmLTQxZjQtYThhMi00YzFmOWY1OWI3NzQ=.jpg?crop=3:2&width=713)
![First look inside.](https://www.thestar.co.uk/webimg/b25lY21zOjZjYzU2NWIxLWU0YTEtNDc3MC1hMGFmLTljYmQyMmE0YjQ3MzowYmEwNDkxOS01MGM4LTRjY2UtYWU3Yy1mNjZlMzNjNjE3ZDI=.jpg?crop=3:2&width=800)